FIGURE 6.

Jia-Wei-Kai-Xin-San treatment modulated proteins relating to Aβ transportation in hippocampus of Aβ injection mice. (A) One group of Aβ injection mice were treated with RAGE antagonist FPS-ZM1 and JWKXS (high dosage) simultaneously. JWKXS was orally treated for 7 days and FPS-ZM1 (dissolved in saline) was injected for 3 days. Then, behavioral tests were carried out and Aβ levels were determined. The Aβ injection mice only injected with saline and treated with JWKXS were applied for contrast. (B) Aβ injection mice were treated with LRP1 antagonist RAP and JWKXS (high dosage) simultaneously. JWKXS was orally treated for 7 days and RAP (dissolved in artificial CSF) was injected for 3 days. Then, behavioral tests were carried out and Aβ levels were determined. The Aβ injection mice only injected with CSF and treated with JWKXS were applied for contrast. Values are expressed in the percentage of sham group, as Mean ± SEM (n = 5). ^∗p < 0.05, ^#p < 0.05.