Fig. 1.

Subgroup analysis of percentage change in LDL-C from baseline to (A) week 12 and (B) week 24 for each study pool stratified by age (ITT analysis). LS means, SEs, and P-values were taken from mixed-effects model with repeated measures analysis. The model includes the fixed categorical effects of treatment group, time point, age group, randomization strata (as per IVRS), treatment-by-time point interaction, age group-by-time point interaction, treatment-by-age group interaction, and treatment-by-age group-by-time point interaction, as well as the continuous fixed covariates of specified baseline lipids parameter value and baseline value-by-time point interaction. Interaction P-value was calculated from the contrasts of interaction test treatment-by-age group at each visit. ALI, alirocumab; CI, confidence interval; ITT, intent-to-treat; IVRS, interactive voice response system, LDL-C, low-density lipoprotein cholesterol; LS, least squares; PBO, placebo; Q2W, every 2 weeks; SE, standard error