Table 2.
Comparison of the frequencies of the tau-immunoreactive pathology (NFT neurofibrillary tangles, NT neuropil threads, DLG dot-like grains, AT astrocytic tangles, EN enlarged neurons, SN surviving neurons, Vac vacuolation) in chronic traumatic encephalopathy (CTE) cases with and without Alzheimer disease neuropathologic change (ADNC) and in ADNC alone. (U upper cortex, M middle layers of cortex, L lower cortex, NS no significant change across cortex)
| Laminar distribution | |||||||
|---|---|---|---|---|---|---|---|
| Cases | Pathology | U | L | U > L | U = L | U < L | NS |
| CTE | NFT | 8 | 0 | 7 | 1 | 0 | 14 |
| NT | 13 | 3 | 4 | 1 | 0 | 12 | |
| DLG | 19 | 3 | 7 | 0 | 0 | 2 | |
| AT | 3 | 1 | 0 | 0 | 0 | 5 | |
| EN | 0 | 4 | 0 | 0 | 0 | 23 | |
| SN | 7 | 0 | 10 | 3 | 1 | 10 | |
| Vac | 16 | 0 | 2 | 4 | 2 | 8 | |
| NP | 0 | 0 | 0 | 0 | 0 | 0 | |
| CTE/ADNC | NFT | 20 | 1 | 5 | 2 | 0 | 26 |
| NT | 19 | 2 | 7 | 2 | 3 | 14 | |
| DLG | 25 | 0 | 16 | 5 | 1 | 7 | |
| AT | 1 | 2 | 1 | 1 | 0 | 21 | |
| EN | 2 | 10 | 0 | 2 | 0 | 38 | |
| SN | 18 | 2 | 11 | 9 | 0 | 16 | |
| Vac | 30 | 5 | 11 | 3 | 0 | 6 | |
| NP | 0 | 0 | 0 | 0 | 0 | 6 | |
| ADNC | NFT | 4 | 4 | 7 | 3 | 0 | 35 |
| NT | 4 | 17 | 5 | 0 | 4 | 11 | |
| DLG | 10 | 2 | 21 | 5 | 2 | 4 | |
| AT | 0 | 1 | 2 | 0 | 1 | 0 | |
| EN | 2 | 17 | 0 | 1 | 1 | 29 | |
| SN | 19 | 1 | 3 | 5 | 1 | 24 | |
| Vac | 32 | 3 | 6 | 1 | 0 | 11 | |
| NP | 13 | 5 | 5 | 0 | 0 | 4 | |
Comparison of frequencies (χ2 contingency tables). CTE compared with CTE/ADNC: NFT χ2 = 3.86 (4DF, P > 0.05), NT χ2 = 3.70 (5DF, P > 0.05), DLG χ2 = 10.67 (5DF, P > 0.05); AT χ2 = 6.44 (4DF, P > 0.05), EN χ2 = 2.61 (3DF, P > 0.05), SN χ2 = 5.55 (5DF, P > 0.05), Vac χ2 = 12.72 (5DF, P < 0.05); Totals for CTE compared with ADNC: NFT χ2 = 15.34 (4DF, P < 0.01), NT χ2 = 28.06 (5DF, P < 0.001), DLG χ2 = 12.15 (5DF, P < 0.05), AT χ2 = 18.70 (5DF, P > 0.01), EN χ2 = 1.41 (4DF, P > 0.05), SN χ2 = 16.12 (5DF, P < 0.01), Vac χ2 = 4.45 (6DF, P > 0.05)