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. 2019 Mar 19;10:408. doi: 10.3389/fimmu.2019.00408

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Copyright © 2019 Wanjalla, McDonnell, Barnett, Simmons, Furch, Lima, Woodward, Fan, Fei, Baker, Ram, Pilkinton, Mashayekhi, Brown, Mallal, Kalams and Koethe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Subcutaneous adipose tissue has a higher percentage of T_EM (CD45RO⁺ CCR7⁻) and T_EMRA (CD45RO⁻ CCR7⁻) cells compared to blood in PLWH. (A) The bar graphs show frequencies of CD4⁺ T_Nai, T_EM, T_CM, and T_EMRA cells in subcutaneous adipose tissue (SAT) and blood (PBMC) from all twenty-six subjects. (B) Frequencies of CD8⁺ T_Nai, T_EM, T_CM, and T_EMRA cells in SAT and PBMC. The numbers in the bar graphs on the left indicate mean and diagonal lines indicate matched pairs of SAT and PBMCs. Wilcoxon matched pair signed test was used to calculate statistics ^****p < 0.0001; ^***p < 0.001.