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. 2019 Mar 19;10:408. doi: 10.3389/fimmu.2019.00408

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Copyright © 2019 Wanjalla, McDonnell, Barnett, Simmons, Furch, Lima, Woodward, Fan, Fei, Baker, Ram, Pilkinton, Mashayekhi, Brown, Mallal, Kalams and Koethe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD4⁺ T cells co-expressing CD57, CX₃CR1, GPR56 in subcutaneous adipose tissue increase with progressive glucose intolerance. viSNE plots were generated in cytobank to identify groups of cells that differ between non-diabetic, pre-diabetic and diabetic categories. (A) Clusters of CD4⁺, T_Nai, T_EM, T_CM, and T_EMRA cells from subcutaneous adipose tissue (SAT). (B) Concatenated viSNE plots of non-diabetic, pre-diabetic, and diabetic PLWH showing clusters of cells expressing CX₃CR1, CD57, GPR56, and CD69. (C) Violin plots showing percentage of total CD4⁺, T_EM, and T_EMRA cells co-expressing CD57, CX₃CR1, and GPR56. Mann-Whitney test used to analyze differences between metabolic groups; ^*P < 0.05.