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. 2019 Feb 14;23(4):2678–2688. doi: 10.1111/jcmm.14167

Figure 5.

Figure 5

Inhibition of EIF5A and sHH signalling pathway decreases PC cells proliferation and tumour growth. A, The MTT results showed that the Panc‐1 cells treatment with Si‐EIF5A combined using Cyc obviously decreased the proliferative ability. (Mean±SD 3.640 ± 0.240 for control, 2.590 ± 0.19 for Si‐EIF5A+sHH group, 4.860 ± 0.350 for sHH group, 3.825 ± 0.425 for Cyc group.) B, The MTT results showed that the BxPc‐3 cells treatment with Si‐EIF5A combined using Cyc obviously decreased the proliferative ability compared with other groups (Mean±SD 4.532 ± 0.280 for control, 3.147 ± 0.49 for Si‐EIF5A+sHH group, 5.192 ± 0.250 for sHH group, 4.019 ± 0.492 for Cyc group.) sHH could significantly increase cells proliferation. *P < 0.05, compared with control, # P < 0.05, compared with the Cyc group. C, Tumour size in mice was measured by the tumour weight, and the sHH group showed a strongly increasing tumour growth, but the group of Si‐EIF5A and Cyc obviously decreases the tumour growth. D, Graphs showed that Si‐EIF5A and sHH signalling could affect the tumour weight. *P < 0.05, compared with the control, # P < 0.05, compared with the sHH group, $ P < 0.05, compared with the group of Si‐EIF5A and Cyc