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. 2019 Mar 25;9:5102. doi: 10.1038/s41598-019-41060-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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3D reconstructions of Hsp70:CHIP-based complexes. The same three orthogonal views of (a) 3D reconstruction of the Hsp70:CHIP complex, with docking of Hsp70 (Hsp70_NBD, green and Hsp70_SBD, orange) and CHIP (pdb 2c2l; red), (b) 3D reconstruction of the Hsp70:CHIP:UbcH5a complex, with docking of Hsp70, CHIP and UbCH5a (pdb 2oxq; dark blue), (c) 3D reconstruction of the Hsp70:CHIP:Bag1s complex, with docking of Hsp70 and Bag1s (from the atomic structure of the Hsp70_NBD:Bag1 complex, pdb: 4hwi; pink), and CHIP. Bar, 100 Å.