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. 2019 Mar 25;2:113. doi: 10.1038/s42003-019-0355-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Administration of 9-cis-retinal partially restored visual function. a The structure of 9-cis-retinoic and all-trans-retinoic acid. b Schema of the protocol for expressing exogenous CLDN19, obtaining baseline multifocal electroretinograms on P60, and administering the light-sensitive retinoids into dark-adapted animals by intraperitoneal injection. c Multifocal electroretinograms were obtained in the light to estimate the amplitude of the P1 wave. Error bars, SEM for 4 mice in each group. *P < 0.05