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. 2019 Mar 19;10:488. doi: 10.3389/fimmu.2019.00488

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Copyright © 2019 Lu, McComish, Burdon, Taylor and Körner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The regulatory effects of VSE1–3 on gene expression. (A) The overlap between VSE1–3 close genes. (B) The visualization of signal density in representative VSE1–3 regions. (C) Average expression level of genes close to different regulatory patterns. (D) The GC content of VSE and VTE. (E) Regulatory effect of different regulatory patterns on gene expressions. VSE, VDR SE; VTE, VDR typical enhancer; VP, VDR promoter binding. To analyse statistical significance, we used a Kruskal–Wallis test followed by Bonferroni correction ^*p < 0.05.