Table 3.
The genes with VSEs that are associated with MS risk SNPs.
| Genes with VSE that within 500 kb of MS risk SNPs | Genes under significant regulation (Log2FC > 1 and p < 0.05) | Genes with high expression level (Log2AverExp > 5) | Both of above |
|---|---|---|---|
| with VSE1 | DENND6B PDCD1LG2 USP2 ASAP2 USP2-AS1 AC080112.2 | DENND6B USP2 ASAP2 AIG1 VPS37B PLXNB2 RNF26 YPEL3 ALDOA PPP4C RARA PPP6R2 ZC3HAV1 TOP2A | DENND6B USP2 ASAP2 |
| with VSE2 | IGLV7-46 SEMA6B NR1I2 LRG1 | SEMA6B LRG1 MYO9B CYTH4 BCL9L ELL MUC1 LCP2 CLCN7 TOP1 TELO2 ZMIZ1 COLGALT1 SLC27A1 RAC2 NR2F6 GSE1 PGLS SLC50A1 FKBP8 IRF8 UBASH3B DPM3 GBA GSK3B UBAC2 THBS3 | SEMA6B LRG1 |
| with VSE3 | LINC00917 AC023590.1 LRRC25 | ELL CUEDC1 IRF5 SLC45A4 RAB3D MRPS7 PLEC RAB44 PLPPR2 CLSTN1 PARP10 MRPS23 SLC25A19 GGA3 GRINA GRB2 TNPO3 PGPEP1 SSBP4 MIF4GD IKZF1 | null |