Table 4.
The gene near SE regions that overlap with MS risk SNPs.
| SE region | Gene in THP-1 cells after 1,25(OH)2D3 stimulation | MS risk SNPs including SNPs in LD region | |||||
|---|---|---|---|---|---|---|---|
| Gene | Log2FC | AveExpr | Coordinate (0-based) | dbSNP ID | RegulomeDB score | ||
| VSE | VSE2 | UBASH3B | −0.1253362 | 5.050095 | chr11:122518524 | rs6589939 | 3a |
| IRF8 | −0.1469718 | 9.341672 | chr16:86005837 | rs68143182 | 5 | ||
| VSE3 | PLEC | −0.5071387 | 8.468479 | chr8:145007946 | rs6989119 | 2a | |
| PARP10 | −0.2369997 | 7.492962 | chr8:145013892 | rs4073081 | 2a | ||
| GRINA | 0.108769 | 7.872264 | chr8:145014731 | rs112979447 | 2a | ||
| PSE | SYK | 0.5603835 | 8.668792 | chr9:93563535 | rs290986 | 5 | |
| UBASH3B | −0.1253362 | 5.050095 | chr11:122527119 | rs7129071 | 2a | ||
| FSE | PLEC | −0.5071387 | 8.468479 | chr8:145007946 | rs6989119 | 2a | |
| PARP10 | −0.2369997 | 7.492962 | chr8:145013892 | rs4073081 | 2a | ||
| GRINA | 0.108769 | 7.872264 | chr8:145014731 | rs112979447 | 2a | ||
| DENND3 | −0.1418788 | 7.662943 | chr8:142104943 | rs4961252 | 5 | ||