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. 2019 Mar 19;10:508. doi: 10.3389/fimmu.2019.00508

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Copyright © 2019 Mantile, Capasso, De Berardinis and Prisco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pre-existing serum titers at recall. The dot plots show the IgG titer against Aβ (A) and E2 (B) at day 273, the day before the recall dose, in mice that displayed memory or no memory against Aβ. Each dot represents a mouse of the SD group (circles), D7B group (triangles), D15B group (squares), D21B group (diamonds). There is no statistically significant difference between memory and no memory mice as regards the antibody titer against Aβ and E2.