FIGURE 2.

Proposed features of Ten-m as a biological oscillator. Data slightly modified from Hunding and Baumgartner (2017), see details therein. Reproduced with permission. (A) Somite formation in an oscillator-based system, as exemplified in chicken (Palmeirim et al., 1997). (B) The Ten-m oscillator as it emerges from a mathematical model. (C) Experimental evidence of emergence of Ten-m stripe formation during early Drosophila gastrulation, starting from ubiquitous Ten-m expression. Double-antibody staining reveals Ten-m in red and Fushi tarazu in green (for comparison). Top part shows the transition from ubiquitous Ten-m expression at early gastrulation to the formation of Ten-m stripes at somewhat later gastrulation (as exemplified of the boxed part comprising stripes 3 and 4 and indicated by an arrow). Bottom part shows enlargements of the formation of Ten-m stripes, again exemplified by stripe 3 and 4 formation and the boxed area. Note that Fushi tarazu (green) is already expressed in stripes from the very beginning, in contrast to Ten-m.