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. 2019 Mar 19;13:51. doi: 10.3389/fnbeh.2019.00051

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Copyright © 2019 Chau, Ranger, Bichin, Park, Amaral, Chakravarty, Poskitt, Synnes, Miller and Grunau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduced regional volumes in limbic system, basal ganglia, and thalamus. This figure displays the results of the constrained principal component analysis. Blue dots representing number of invasive procedures (component 1) are displayed on the brain regions that were significantly altered. Green dots representing more surgeries (component 2) are displayed on brain regions that were bilaterally reduced by the number of neonatal surgeries. Red dots, representing the interaction term between neonatal clinical factors and genotypes, show the two brain regions significantly related to this interaction term. PC1, principal component 1; PC2, principal component 2; PC NCFxG, principal component of the interaction term between neonatal clinical factors and genotypes.