Table 1.
Participant characteristics.
| Neonatal | N = 57 (26 boys, 31 girls) |
|---|---|
| Gestational age at birth (GA, wks) | 29.7 (27.6–31.7) |
| Birth weight (g) | 1285 (920–1560) |
| Small for gestational age (n, %) | 6 (11) |
| Illness severity day 1 (SNAP-II) | 8 (0–18.5) |
| Pain/stress (# invasive procedures) | 74 (46.5–131) |
| Infants mechanically ventilated (n, %) | 35 (61.4) |
| Days of mechanical ventilation | 9 (0–71) |
| Culture proven infection (n, %) | 14 (24.6) |
| Surgery (n, %) | 11 (19.3) |
| Morphine exposure (mg/kgI) | 0.03 (0–0.7) |
| Postnatal corticosteroid exposure (n, days) | 6 (2–24) |
| Child | Mean (range) |
| Age at scan (years) | 7.9 (7.7–8) |
| Total brain volume (cm3) | 1397.0 (1123.4–1759.0) |
| Total right/left hippocampal volume (cm3) | 214 (199–234)/221 (201–236) |
| Total right/left amygdala volume | 111 (108–123)/117 (109–125) |
| Total right/left thalamus volume | 623 (582–668)/588 (551–629) |
| WISC-IV Full Scale IQ | 101 (73–135) |
| WISC-IV VCI | 100 (77–136) |
| WISC-IV PRI | 104 (69–147) |
| WISC-IV WMI | 99 (77–120) |
| WISC-IV PSI | 98 (75–131) |
| CBCL Internalizing Problems | 53 (34–80) |
| CBCL Externalizing Problems | 48 (33–77) |
| BRIEF GEC | 53 (35–86) |
| Beery Visual Motor Integration | 94 (75–112) |
| Beery Visual Perception | 105 (77–143) |
| Beery Motor Coordination | 92 (60–113) |
WISC-IV, Wechsler Intelligence Scale for Children 4th Ed; VCI, Verbal Comprehension Index; PRI, Perceptual Reasoning Index; WMI, Working Memory Index; PSI, Processing Speed Index; CBCL, Child Behavior Checklist; BRIEF, Behavior Rating Inventory of Executive Function; GEC, Global Executive Composite; Beery VMI, Beery Visual Motor Integration. Values are means and ranges, unless otherwise specified. ICumulative daily dose adjusted for daily body weight multiplied by the number of days drug received.