Table 4.
CPCA component loadings predicted by neonatal clinical factors (NCF) and genotypes (G) independently and interactively.
| PC1 |
PC2 |
PC NCFxG |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Brain Regions | Loadings | p-valuea | FDRb | Loadings | p-valuea | FDRb | Loadings | p-valuea | FDRb |
| L_CA1 | -0.259 | 0.093 | 0.105 | -0.950 | 0.0000 | 0.000 | -0.751 | 0.060 | 0.156 |
| L_subiculum | -0.510 | 0.042 | 0.049 | -0.736 | 0.0120 | 0.017 | -0.130 | 0.758 | 0.984 |
| L_CA4DG | -0.764 | 0.000 | 0.000 | -0.562 | 0.0004 | 0.001 | -0.738 | 0.018 | 0.058 |
| L_CA2CA3 | -0.521 | 0.166 | 0.180 | -0.610 | 0.2175 | 0.226 | -0.556 | 0.052 | 0.150 |
| L_stratum | -0.432 | 0.006 | 0.009 | -0.860 | 0.0000 | 0.000 | -0.815 | 0.009 | 0.036 |
| R_CA1 | -0.427 | 0.005 | 0.009 | -0.859 | 0.0001 | 0.000 | -0.909 | 0.009 | 0.036 |
| R_subiculum | -0.634 | 0.001 | 0.001 | -0.720 | 0.0004 | 0.001 | -0.254 | 0.476 | 0.858 |
| R_CA4DG | -0.726 | 0.000 | 0.000 | -0.646 | 0.0002 | 0.000 | -0.802 | 0.000 | 0.003 |
| R_CA2CA3 | -0.584 | 0.033 | 0.040 | -0.664 | 0.0283 | 0.037 | -0.607 | 0.009 | 0.036 |
| R_stratum | -0.425 | 0.007 | 0.010 | -0.887 | 0.0000 | 0.000 | -0.829 | 0.010 | 0.036 |
| L_Alveus | -0.570 | 0.012 | 0.016 | -0.739 | 0.0116 | 0.017 | -0.773 | 0.006 | 0.036 |
| L_Fimbria | -0.850 | 0.000 | 0.000 | -0.361 | 0.1050 | 0.114 | -0.257 | 0.495 | 0.858 |
| L_Fornix | -0.642 | 0.000 | 0.000 | -0.649 | 0.0001 | 0.000 | -0.029 | 0.970 | 0.984 |
| L_Mam | -0.350 | 0.469 | 0.469 | -0.443 | 0.4073 | 0.407 | 0.282 | 0.384 | 0.832 |
| R_Alveus | -0.552 | 0.026 | 0.034 | -0.663 | 0.0128 | 0.018 | -0.819 | 0.000 | 0.003 |
| R_Fimbria | -0.800 | 0.000 | 0.000 | -0.475 | 0.0054 | 0.009 | -0.277 | 0.460 | 0.858 |
| R_Fornix | -0.708 | 0.000 | 0.000 | -0.651 | 0.0000 | 0.000 | -0.457 | 0.379 | 0.832 |
| R_Mam | -0.456 | 0.206 | 0.214 | -0.684 | 0.0590 | 0.067 | 0.181 | 0.588 | 0.899 |
| L_amygdala | -0.761 | 0.000 | 0.000 | -0.611 | 0.0000 | 0.000 | -0.326 | 0.534 | 0.867 |
| R_amygdala | -0.820 | 0.000 | 0.000 | -0.516 | 0.0001 | 0.000 | 0.217 | 0.718 | 0.982 |
| L_striatum | -0.824 | 0.000 | 0.000 | -0.484 | 0.0005 | 0.001 | 0.217 | 0.817 | 0.984 |
| L_gp | -0.895 | 0.000 | 0.000 | -0.363 | 0.0350 | 0.043 | 0.263 | 0.644 | 0.930 |
| L_thalamus | -0.832 | 0.000 | 0.000 | -0.475 | 0.0034 | 0.006 | -0.036 | 0.953 | 0.984 |
| R_striatum | -0.811 | 0.000 | 0.000 | -0.505 | 0.0003 | 0.001 | 0.123 | 0.890 | 0.984 |
| R_gp | -0.905 | 0.000 | 0.000 | -0.357 | 0.0381 | 0.045 | 0.043 | 0.944 | 0.984 |
| R_thalamus | -0.831 | 0.000 | 0.000 | -0.467 | 0.0061 | 0.010 | -0.011 | 0.984 | 0.984 |
Negative loadings for each component indicate smaller regional volumes. The bigger the negative loading, the smaller the regional volume. PC1 principal component 1; PC2, principal component 2; PC NCFxG, principal component of the interaction term between neonatal clinical factors and genotypes; L, left; R, right. Left and right hippocampal subfields: cornus ammonis (CA) 1, subiculum, CA4/dentate gyrus (DG), CA2/CA3, stratum radiatum/lacunosum/molecular; Left and right hippocampal white matter: alveus, fimbria, fornix, and mammillary bodies (Mam); Left and right amygdala; Left and right basal ganglia: striatum, globus pallidus (gp) and thalamus. aRed font indicates p < 0.0045 after Bonferroni adjustment for multiple comparisons. bRed font indicates p < 0.05 after Benjamini–Hochberg false discovery rate (FDR) 5% overall error rate adjustment.