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. 2019 Mar 19;10:524. doi: 10.3389/fimmu.2019.00524

Figure 5.

Figure 5

Model of PRMT5 expression regulation after Th cell activation. (A) In naive T cells, NF-κB drives Prmt5 transcription and the NF-κB/mTOR/MYC axis drives PRMT5 protein induction through post-transcriptional and/or translational mechanisms. (B) In memory T cells, the NF-κB/mTOR/MYC axis drives PRMT5 protein induction through predominantly non-transcriptional mechanisms. Prmt5 transcription and miRNA loss may further contribute to PRMT5 induction via NF-κB/mTOR/MYC-independent mechanisms.