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. 2019 Mar 19;13:143. doi: 10.3389/fnins.2019.00143

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Copyright © 2019 Aftab, Mesnil, Ojefua, Poole, Noordenbos, Strale, Sitko, Le, Stoynov, Foster, Sin, Naus and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MMP3 is active in the ECM of high motility glioma. (A) SDS-PAGE/Western blot demonstrates the binary increases of MMP3 in C6-13 vs. C6 glioma conditioned media (CM) in 3 biological replicates. (B) Increases in gelatinase activity associated with MMP3 is observed in the conditioned media of C6-13, but not C6 cells. (C) Cleavage of the MMP3-specific fluorgenic substrate (NFF-3) demonstrates increased proteolytic activity in C6-13 CM. Limited cleavage of NFF-3 is observed with C6. Fresh, unconditioned media served as a negative control for each time point. (D) Representative, quantitative values from the 2 h time point demonstrates robust increases in MMP3 activity with C6-13.