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. 2019 Mar 19;13:143. doi: 10.3389/fnins.2019.00143

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Copyright © 2019 Aftab, Mesnil, Ojefua, Poole, Noordenbos, Strale, Sitko, Le, Stoynov, Foster, Sin, Naus and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulators of cellular movement are significantly enriched in glioma secretome. (A) Heat map representation of secretome proteins and functional relationships. Lighter colors in this heat map group proteins that are statistically enriched for the listed cell function (y-axis). Protein network enrichment and statistical significance were determined by Ingenuity Pathways^TM. (B) Cell Movement (P = 2.15 × 10^-16) was the most statistically significant network encoded by the secretome of C6/C6-13 cells. Migration subnetworks (and P-values) comprising the Cellular Movement category. (C) Color bin histogram representing the distribution of both significant (x-axis: left, light) and non-significant (right, dark) protein networks represented in Figure 6A.