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. 2019 Mar 19;13:143. doi: 10.3389/fnins.2019.00143

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Copyright © 2019 Aftab, Mesnil, Ojefua, Poole, Noordenbos, Strale, Sitko, Le, Stoynov, Foster, Sin, Naus and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integrated analysis of Cx43 secretome and Cx43 protein–protein interactions reveals synergistic networks. Radar plots of pathways associated with the Cx43 (A) secretome, and (B) interactome plotted as -log P-value. C) Analysis of Cx43 networks demonstrates the coherence of “Apoptosis,” “Migration,” “Cell Death and Survival,” “Cellular Movement,” and “Proliferation” between Cx43-protein interactions and secretome. (D) Downstream impact analysis (IPA) identifies interactions of Cx43 implicated with migration. Based on IPA informatics (Activation Z-Score) the majority of these interactions are expected to increase migration.