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. 2019 Mar 19;13:217. doi: 10.3389/fnins.2019.00217

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Copyright © 2019 Mu, Li, Wang, Li, Bai, Zhang and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brain overview and myelin loss in DAI (diffuse axonal injury). (A) An overview of brain morphology determined on H&E-stained. Squares show ROIs focused on the CC and brain stem evaluated in the present study; (B–D) LFB staining at 3 and 7 days post-injury shows myelin disruption and myelin loss in the corona radiate and brain stem; (E) western blot analysis indicates that MBP expression was significantly decreased throughout the first week after injury in brain stem. The CC region exhibits significant decreased MBP expression at 3 days after injury. N.S. indicates no significant changes between DAI group and control group.