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. 2019 Mar 25;9:5049. doi: 10.1038/s41598-019-41509-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative enhanced-depth imaging OCT images of the central macula showing post-binarization overlay of the region of interest on the scans demonstrating the luminal and stromal areas (yellow) in eyes from a normal age-matched patient (A–C), with non-exudative AMD (D–F) and with exudative AMD (G–I), before (A,D,G), and at 1 hour (B,E,H) and 3 hours (C,F,I) after a 100 mg oral dose of sildenafil citrate. Line graphs show a greater relative increase in stromal area (K) than luminal area (J) in the choroid.