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. 2019 Mar 25;9:5049. doi: 10.1038/s41598-019-41509-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative en-face OCT-A images of the central macula showing superficial retinal vessel density values measured from the central 1 mm diameter circle, and each quadrant of the 1–3 mm diameter inner ring and 3–6 mm diameter outer ring of the Early Treatment of Diabetic Retinopathy Study grid, in eyes taken a normal age-matched patient (A–C), with non-exudative AMD (D–F) and with exudative AMD (G–I), before (A,D,G), and at 1 hour (B,E,H) and 3 hours (C,F,I) after a 100 mg oral dose of sildenafil citrate. Line graphs show no significant change in the total retinal vessel density (J) or inner ring retinal vessel density (K) after sildenafil in either normal or AMD eyes.