Table 1.
Choroidal and retinal vascular changes after sildenafil citrate in AMD and normal eyes.
| Age-matched normal eyes (n = 16) | Non-exudative AMD eyes (n = 15) | Exudative AMD eyes (n = 15) | P-value* | |
|---|---|---|---|---|
| Choroidal thickness (mm) | 0.464 | |||
| Baseline | 207.5 ± 77.7 | 172.1 ± 60.0 | 196.4 ± 89.8 | |
| 1 hour | 220.5 ± 82.5 | 183.5 ± 69.3 | 208.2 ± 95.4 | |
| 3 hour | 225.3 ± 81.7 | 187.6 ± 73.6 | 211.0 ± 108.0 | |
| Choroidal luminal area (mm 2 ) | 0.203 | |||
| Baseline | 0.90 ± 0.12 | 0.76 ± 0.19 | 0.84 ± 0.24 | |
| 1 hour | 0.92 ± 0.14 | 0.80 ± 0.21 | 0.85 ± 0.21 | |
| 3 hour | 0.92 ± 0.14 | 0.80 ± 0.22 | 0.81 ± 0.22 | |
| Choroidal stromal area (mm 2 ) | 0.109 | |||
| Baseline | 0.37 ± 0.06 | 0.33 ± 0.09 | 0.43 ± 0.14 | |
| 1 hour | 0.40 ± 0.07 | 0.36 ± 0.10 | 0.45 ± 0.13 | |
| 3 hour | 0.42 ± 0.07 | 0.37 ± 0.11 | 0.44 ± 0.13 | |
| Total retinal vascular density (%) | 0.281 | |||
| Baseline | 17.7 ± 1.8 | 13.9 ± 6.9 | 16.3 ± 1.9 | |
| 1 hour | 15.1 ± 3.0 | 14.3 ± 7.3 | 16.7 ± 3.0 | |
| 3 hour | 16.7 ± 2.9 | 12.4 ± 6.0 | 15.6 ± 1.9 | |
| Inner circle retinal vascular density (%) | 0.587 | |||
| Baseline | 17.2 ± 3.5 | 17.0 ± 1.6 | 17.0 ± 2.2 | |
| 1 hour | 15.2 ± 3.0 | 17.2 ± 2.5 | 17.0 ± 3.1 | |
| 3 hour | 17.1 ± 2.6 | 14.6 ± 2.5 | 16.5 ± 1.8 |
*P-value based on repeated measures ANOVA with time as within-subject and AMD type as between-subject variables.