Table 1.
List of the Ser and Thr residues in HSP90 that were subjected to mutagenesis. Three-letter amino acid codes apply.
| Position | Reference | Constitutive de-phosphorylation | Phosphomimetic exchange | Surrounding Sequence |
|---|---|---|---|---|
| Thr21 | (Mollapour et al., 2011) | Thr21 – Ile21 | Thr21 – Asp21 | Ser-Leu-Ile-Ile-Asp-Thr-Phe-Tyr-Ser-Asn-Lys |
| Thr100 | (Hawle et al., 2006) | Thr100 – Ile100 | Thr100 – Asp100 | Ile-Ala-Arg-Ser-Gly-Thr-Lys-Ala-Phe-Met-Glu |
| Thr211 | this paper | Thr211 – Ala211 | Thr211 – Asp211 | Met-Val-Glu-Lys-Thr-Thr-Glu-Lys-Glu-Val-Thr |
| Thr216 | this paper | Thr216 – Ala216 | Thr216 – Asp216 | Thr-Glu-Lys-Glu-Val-Thr-Asp-Glu-Asp-Glu-Glu |
| Thr223 | (Morales et al., 2010) | Thr223 – Ala223 | Thr223 – Asp223 | Glu-Asp-Glu-Glu-Asp-Thr-Lys-Kys-Ala-Ala-Glu |
| Ser289 | this paper | Ser289 – Ala289 | Not done | Phe-Tyr-Lys-Ala-Ile-Ser-Asn-Asp-Trp-Glu-Asp |
| Ser526 | (Morales et al., 2010) | Ser526 – Ala526 | Not done | Val-His-Phe-Glu-Glu-Ser-Glu-Glu-Glu-Lys-Gln |
| Ser594 | this paper | Ser594 – Ala594 | Ser594 – Asp594 | Gln-Ala-Lys-Arg-Asp-Ser-Ser-Met-Ala-Gln-Tyr-Met |
| Ser595 | this paper | Ser595 – Ala595 | Ser595 – Asp595 | Gln-Ala-Leu-Arg-Asp-Ser-Ser-Met-Ala-Gln-Tyr-Met |
| Thr693 | (Muller et al., 2013) | Thr693 – Ala693 | Thr693 – Asp693 | Glu-Val-Thr-Ala-Gly-Thr-Ser-Ser-Met-Glu-Gln-Val-Asp |
| Ser694 | (Muller et al., 2013) | Ser694 – Ala694 | Ser694 – Asp694 | Glu-Val-Thr-Ala-Gly-Thr-Ser-Ser-Met-Glu-Gln-Val-Asp |