Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 25;9:5084. doi: 10.1038/s41598-019-41587-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Magnetization-transfer MRI provides proton-density contrast in brain while saturating extracellular free water protons. (a) Comparison of M₀ map and (α15MT) proton-density-weighted as well as (α70MT) T₁-weighted MRI with magnetization transfer. Note the similar contrast between M₀ and α15MT for the entire intracranial tissue, the similar contrast for all three images within the regions-of-interest selected in brain (white lines), as well as the saturation of free water protons in the cerebrospinal fluid (arrows) in α70MT. (b) Pixel-by-pixel plots of α70MTR vs. T₁, (c) of signal intensities in α15MT vs. M₀, (d) of signal intensities in α70MT vs. M₀, (e) of signal intensities in α70MT vs. α15MT for the entire intracranial tissue, (f) of signal intensities in α70MT vs. M₀, and (g) of signal intensities in α70MT vs. α15MT for the regions-of-interest shown in (a). Note the significant (p < 0.0005) correlation in (b), (c), (f), and (g). A pool of pixels (arrows) with high signal intensity in M₀ as well as in α15MT can be identified in (c). Strong on-resonance irradiation (d,e) results in a downward deviation of a pool of comparable size. These pixels are supposed to be dominated by free water protons. Functions and correlation coefficients are: (b) y = −0.0157x + 58.4, r = −0.84, (c) y = 0.3396x + 2.86, r = 0.87, (f) y = 0.3423x + 169.2, r = 0.80, and (g) y = 1.2925x + 145.4, r = 0.77.