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. 2019 Mar 25;9:5084. doi: 10.1038/s41598-019-41587-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) (Upper row) Parasagittal T₁-weighted MRI (2.35T, RF-spoiled 3D FLASH, TR/TE = 30/7.6 ms, α 25°, 117 µm isotropic resolution, total acquisition = 4 hours) of the locus coeruleus and (lower row) the A2 cell groups of an 8-week-old female NMRI mouse (left column) without magnetization transfer, (middle column) with magnetization transfer (Δf = 5000 Hz, ω_SAT = 1045°/12 ms), and (right column) magnetization-transfer ratio map (scale: 0–50%). (b) Parasagittal MRI (2.35T, RF-spoiled 3D FLASH, TR/TE = 30/7.6 ms, flip angle 22°, Δf = 2500 Hz, ω_SAT = 523°/12 ms, 117 µm isotropic resolution) of the locus coeruleus and (c) A2 cell group of a 3-week-old male NMRI mouse. (d) Horizontal and (e–g) coronal MRI of the same animal showing the planes indicated in (b,c). A2 = A2 cell group, Hp = pyramidal cell layer of the hippocampus, LC = locus coeruleus, PCL = Purkinje cell layer of the cerebellum, arrowheads = marginal nuclei of the brachium conjunctivum.