Table 2.
Subject characteristics of the cross‐sectional cohort
| LHC | OB | T2DM | |
|---|---|---|---|
| N (sex) | 14 (6 m, 8f) | 12 (7 m, 5f) | 10 (5 m, 5f) |
| Age (yrs.) | 31 ± 1 | 66 ± 1[Link] | 62 ± 3[Link] |
| Weight (kg) | 64 ± 3 | 100 ± 4[Link] | 94 ± 5[Link] |
| BMI (kg/m2) | 22 ± 1 | 35 ± 1[Link] | 33 ± 1[Link] |
| FPG (mg/dL) | 91 ± 1 | 101 ± 2[Link] | 125 ± 9[Link] , [Link] |
| GDR (“M,” mg/kg/min) | 6.4 ± 0.5 | 2.5 ± 0.3[Link] | 2.7 ± 0.4[Link] |
|
Insulin Sensitivity (“M/I”) (mg/kg/min/μU.mL) |
0.115 ± 0.010 | 0.027 ± 0.004[Link] | 0.025 ± 0.005[Link] |
Data represent mean ± SEM.
LHC, lean healthy control subjects; OB, obese individuals with insulin resistance; T2DM, individuals with Type 2 Diabetes Mellitus; BMI, Body Mass Index; FPG, fasting plasma glucose; GDR, glucose disposal rate as calculated from the hyperinsulinemic‐euglycemic clamp; M/I, clamp‐derived glucose disposal rate normalized to prevailing insulin concentration; 1different from LHC; 2different from OB; one‐way ANOVA with Bonferroni post hoc test P < 0.05.