Table 3.
Metabolic characteristics of the lifestyle intervention cohort
| PRE | POST | |
|---|---|---|
| N | 18 (11 m, 7f) | 18 |
| Age (yrs.) | 66 ± 1 | – |
| Weight (kg) | 97.9 ± 3.7 | 89.5 ± 3.1[Link] |
| BMI (kg/m2) | 34.5 ± 1.0 | 31.5 ± 0.9[Link] |
| Fat Free Mass (kg) | 56.3 ± 2.7 | 56.1 ± 2.7 |
| VO2max (mL/kg/min) | 21.6 ± 0.8 | 28.1 ± 1.5[Link] |
| FPG (mg/dL) | 109 ± 4 | 101 ± 3[Link] |
| GDR (mg/kg/min) | 2.6 ± 0.3 | 4.2 ± 0.3[Link] |
| M/I (mg/kg/min/μU.mL) | 0.024 ± 0.003 | 0.041 ± 0.005[Link] |
| RQ (AU) | 0.84 ± 0.01 | 0.83 ± 0.01 |
| Metabolic Flexibility (AU) | 0.03 ± 0.01 | 0.06 ± 0.01[Link] |
| Fat OxidationBasal (mg/kg FFM/min) | 1.11 ± 0.10 | 1.10 ± 0.12 |
| Fat OxidationInsulin (mg/kg FFM/min) | 0.76 ± 0.08 | 0.57 ± 0.07[Link] |
| COX (mg/kg FFM/min) | 2.06 ± 0.24 | 1.95 ± 0.26 |
| NOGD (mg/kg FFM/min) | 1.7 ± 0.6 | 4.1 ± 0.6[Link] |
| Glycogen ContentBasal (mmol/kg wet wt.) | 88 ± 10 | 105 ± 5[Link] |
| Glycogen ContentInsulin (mmol/kg wet wt.) | 102 ± 9 | 155 ± 8[Link] |
Data represent mean ± SEM.
The OB and T2DM subjects from the cross‐sectional analysis have been combined into PRE and POST, which represents data collection points before and after the intensive lifestyle intervention; BMI, Body Mass Index; GDR, Glucose Disposal Rate as calculated from the hyperinsulinemic‐euglycemic clamp; VO2max, maximal oxygen consumption during maximal aerobic exercise testing; COX, Carbohydrate Oxidation; NOGD, Nonoxidative Glucose Disposal; BMR, Basal Metabolic Rate; RQ, Respiratory Quotient; FPG, Fasting Plasma Glucose; M/I, GDR normalized to the prevailing insulin concentration during the final 90–120 min of the hyperinsulinemic‐euglycemic clamp (mg/kg/min/μU.mL); 1significant effect of the 12‐week intensive lifestyle intervention; paired sample t‐test, P < 0.05.