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. 2019 Mar 25;9:5039. doi: 10.1038/s41598-019-41527-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of CFZ on the expression and activation of ER stress-associated proteins in SK-N-BE(2)-M17 cells. (A) Cells were treated with various concentrations (20–400 nM) of CFZ for 24 h (CFZ-dose) or treated with 200 nM CFZ for the indicated durations (CFZ-time). (B) Cells were treated with 200 nM CFZ for 0.5–2 h. Cell lysates from (A,B) were prepared and resolved by SDS-PAGE. Changes in the levels of ER stress-associated proteins were examined by western blot analysis with antibodies against GRP94, GRP78, cleaved ATF6α, ATF4, XBP1, CHOP, P-eIF2α, eIF2α, and β-actin. Results shown are representative of those obtained in more than three independent experiments.