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. 2017 Jul 7;37(4):BSR20170680. doi: 10.1042/BSR20170680

Figure 6. MAPK was the upstream of NFκB signaling in CFTR-mediated macrophages.

Figure 6

(A–D) Peritoneal macrophages were pretreated with CFTRinh-172 (10 μM) for 24 h followed by incubation with ox-LDL (80 μg/ml) for another 24 h in the presence or absence of PD98059 (10 μM), SP600125 (10 μM), or BAY11 (20 μM). Nuclear (A) and cytosol (B) distribution of p65, and JNK (C) and ERK (D) phosphorylation were examined by Western blotting. **P<0.01 compared with control; ##P<0.01 compared with ox-LDL; $$P<0.01 compared with ox-LDL + CFTRinh-172, n=6.