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Coculture of human PBMC with LMWM-ESP, SE-MeOH, and SE-HDA at a final concentration of 20 μg/ml prior to stimulation with LPS resulted in significant supression of cytokines that are important in IBD. (A) IL-1β; (B) IL-6; (C) IL-10; (D) TNF-α; (E) MCP-1. Statistical analyses were performed using GraphPad Prism 7 (one-way ANOVA).
