FIG 1.

Mepacrine protects mice from CPE-induced lethal enterotoxemic death. Mouse intestinal loops received an injection of 1 ml of HBSS containing 100 μg of CPE plus 1.0 mM mepacrine (n = 20), 100 μg of CPE plus 0.5 mM mepacrine (n = 10), 100 μg of CPE alone (n = 20), or 1.0 mM mepacrine alone (n = 10). Incubation of intestinal loops took place for 4 h or until the animals died spontaneously. Mice were observed, and time to death was recorded and plotted. Kaplan-Meier survival curves were compared using log-rank analysis. A P value of <0.05 was regarded as statistically significant. *, P < 0.05 compared with blue and red lines; ns, not significant.