FIG 6.

Contributions of TolC orthologs to F. tularensis Schu S4 virulence in mice via the intranasal route. Mice were infected intranasally with the indicated doses of either WT Schu S4 or the ΔtolC mutant (A), ΔftlC mutant (B), or ΔsilC mutant (C) and monitored for survival for 21 days (for all strains, n = 10 mice). (D) Mice were infected with 50 CFU of the WT, the ΔtolC mutant, or the complemented Schu S4 strain and monitored for survival for 21 days (for WT-infected mice, n = 3; for all others, n = 5). **, P < 0.01; ***, P < 0.001; calculated by log rank test.