FIG 5.

Myd88^−/− mice that succumb to Y. pestis CO92 infection have reduced inflammatory foci and tissue necrosis. Lungs (A and D), livers (B and E), and spleens (C and F) from Myd88^−/− (A to C) and C57BL/6 (D to F) mice that were challenged with Y. pestis CO92 and succumbed to disease were fixed in formalin and processed for histology. (A to F) Representative lesions; (G) severity scoring of inflammatory infiltrate and necrosis. Bars indicate standard deviations; data were collected in 3 independent trials (n = 14 WT mice, n = 20 Myd88^−/− mice). Scale bar, 100 μm. Data were analyzed by an unpaired Student’s t test. ****, P < 0.0001; NS, not significant.