Table 3.
Association of rs2070424 polymorphism with IGR and T2D.
| Controls, n (%) | Cases, n (%) | Crude OR (95% CI) | P Value | Adjusted OR (95% CI)a | P value | |
|---|---|---|---|---|---|---|
| IGR vs. NGT | ||||||
| GG genotype | 320 (31.87) | 125 (24.41) | 1 | 1 | ||
| AG genotype | 473 (47.11) | 240 (46.88) | 1.30 (1.00–1.68) | <0.01 | 1.34 (1.02–1.75) | <0.01 |
| AA genotype | 211 (21.02) | 147 (28.71) | 1.78 (1.33–2.40) | <0.01 | 1.84 (1.35–2.50) | <0.01 |
| AG + AA genotype | 684 (68.13) | 387 (75.59) | 1.45 (1.14–1.84) | <0.01 | 1.49 (1.16–1.92) | <0.01 |
| T2D vs. NGT | ||||||
| GG genotype | 320 (31.87) | 237 (23.61) | 1 | 1 | ||
| AG genotype | 473 (47.11) | 501 (49.90) | 1.43 (1.16–1.76) | <0.01 | 1.44 (1.15–1.81) | <0.01 |
| AA genotype | 211 (21.02) | 266 (26.49) | 1.70 (1.33–2.18) | <0.01 | 1.74 (1.33–2.28) | <0.01 |
| AG + AA genotype | 684 (68.13) | 767 (76.39) | 1.51 (1.24–1.84) | <0.01 | 1.53 (1.24–1.90) | <0.01 |
| (IGR & T2D) vs. NGT | ||||||
| GG genotype | 320 (31.87) | 362 (22.67) | 1 | 1 | ||
| AG genotype | 473 (47.11) | 741 (49.62) | 1.39 (1.15–1.67) | <0.01 | 1.38 (1.13–1.69) | <0.01 |
| AA genotype | 211 (21.02) | 413 (27.71) | 1.73 (1.38–2.16) | <0.01 | 1.77 (1.40–2.25) | <0.01 |
| AG + AA genotype | 684 (68.13) | 1154 (77.33) | 1.49 (1.25–1.78) | <0.01 | 1.50 (1.24–1.81) | <0.01 |
a
ORs were adjusted for sex, age (≤40, 40–49, 50–59, ≥60), BMI (≤18.5, 18.5–23.9, 24–27.9, ≥28), smoking (current, former, and never), drinking (current, former, and never), physical activity (yes or no), hypertension (yes or no), and family history of diabetes (any or none).