Table 4.
ORs for the association between IGR, T2D and plasma copper concentrations according to gene polymorphisma.
| Variables | Tertiles of plasma copper concentration (mg/L) |
P value for trend | Per SD of ln-transformed plasma copper | P-interaction | ||
|---|---|---|---|---|---|---|
| Q1 |
Q2 |
Q3 |
||||
| <797.39 (709.25)b | 797.39–956.13 (875.06)b | ≥956.13 (1048.06)b | ||||
| IGR vs. NGT | ||||||
| GG | 1 | 1.51 (0.85–2.69) | 3.02 (1.73–5.26) | <0.001 | 1.69 (1.33–2.14) | 0.009 |
| AG | 1 | 1.09 (0.71–1.69) | 1.61 (1.05–2.46) | <0.001 | 1.34 (1.13–1.59) | |
| AA | 1 | 0.94 (0.51–1.72) | 1.24 (0.70–2.22) | 0.380 | 1.24 (0.99–1.55) | |
| T2D vs. NGT | ||||||
| GG | 1 | 2.88 (1.66–4.97) | 6.57 (3.90–11.05) | <0.001 | 2.40 (1.93–2.99) | 0.035 |
| AG | 1 | 1.53 (1.04–2.28) | 3.49 (2.39–5.09) | <0.001 | 1.85 (1.59–2.16) | |
| AA | 1 | 1.57 (0.87–2.83) | 3.24 (1.87–5.62) | <0.001 | 1.76 (1.44–2.15) | |
| (IGR & T2D) vs. NGT | ||||||
| GG | 1 | 2.12 (1.37–3.28) | 4.52 (2.95–6.91) | <0.001 | 1.99 (1.66–2.38) | 0.005 |
| AG | 1 | 1.34 (0.96–1.87) | 2.57 (1.85–3.56) | <0.001 | 1.60 (1.41–1.83) | |
| AA | 1 | 1.20 (0.73–1.97) | 2.12 (1.32–3.44) | <0.001 | 1.51 (1.27–1.79) | |
a
ORs were adjusted for sex, age (≤40, 40–49, 50–59, ≥60), BMI (≤18.5, 18.5–23.9, 24–27.9, ≥28), smoking (current, former, and never), drinking (current, former, and never), physical activity (yes or no), hypertension (yes or no), and family history of diabetes (any or none).
b
Range (median).