Skip to main content
. 2019 Mar 26;7(6):e14018. doi: 10.14814/phy2.14018

Figure 1.

Figure 1

Short‐term simvastatin treatment of old mdx mice reverses left ventricular diastolic dysfunction. In these experiments, mdx mice were treated with Simvastatin (80 mg/kg food) starting at 12 months of age for a total of 8 weeks. (A) Representative recording showing the method of analysis for the myocardial performance index (MPI). (B) Pooled data showing the changes in MPI over time. The first measurement was taken when mice were 12 months of age (Time, 0 weeks). *P < 0.05 versus mdx Con, ***P < 0.001 versus mdx Con, ***P < 0.001 versus mdx Con and mdx Sim, # P < 0.05 versus mdx Sim, ### P < 0.001 versus mdx Con. (C) Representative recording showing the method of analysis for the E’/A’ ratio, a measure of diastolic function (D) Pooled data showing the changes in the E’/A’ ratio over time. Note that a ratio > 1.0 is considered a normal value (dotted line). **P < 0.01 versus mdx Con, *P < 0.05 versus mdx Sim, ***P < 0.001 versus mdx Con and mdx Sim, ### P < 0.001 versus mdx Con. WT (n = 6), mdx Con (n = 6), mdx Sim (n = 7).