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. 2019 Mar 26;7(6):e14018. doi: 10.14814/phy2.14018

Figure 2.

Figure 2

Simvastatin increases expression of p‐PLB‐S16, a key regulator of SERCA2a activity. (A) Representative Western blot showing the expression of Phospholamban phosphorylated at serine 16 (p‐PLB‐S16) and total Phospholamban (PLB total) from cardiac muscle of 14‐month‐old WT mice and mdx mice with or without 8 weeks of simvastatin treatment. Pooled data showing individual values and the mean expression levels of (B) PLB total and (C) p‐PLB‐S16. **P < 0.01 versus mdx Con, ***P < 0.001 versus WT, *P < 0.05 versus mdx Con. Data are shown as the mean ± SEM. WT (n = 6), mdx Con (n = 6), mdx Sim (n = 7). (D) Representative Western blot showing the expression of SERCA2a. (E) Pooled data showing individual values and the mean expression levels of SERCA2a.