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. 2019 Mar 26;7(6):e14018. doi: 10.14814/phy2.14018

Figure 4.

Figure 4

Long‐term simvastatin treatment provides sustained improvement of left ventricular diastolic function in mdx mice. In this study, mdx mice were treated with two doses of Simvastatin (40 or 80 mg/kg food) starting at 6 months of age for a total of 12 months treatment. WT mice were also used for this study. (A) Myocardial Performance Index (MPI), was measured by echocardiography every 2 months. The baseline measurement was taken when mice were 6 months of age (Time, 0 weeks). *P < 0.05 versus mdx Con, **P < 0.01 versus mdx Con, ***P < 0.001 versus mdx Con, *P < 0.05 versus mdx Con, ***P < 0.001 versus mdx Con. ***P < 0.001 versus all groups. (B) Diastolic function using the E’/A’ ratio. A ratio > 1.0 is considered a normal value (dotted line). *P < 0.05 versus mdx Con, *P < 0.05 versus mdx Con, **P < 0.01 versus mdx Con, **P < 0.01 versus all groups,***P < 0.001 versus all groups, # P < 0.05 versus mdx Con and mdx Sim 40, ## P < 0.01 versus mdx Con and mdx Sim 40, ### P < 0.001 versus mdx Con. At the start of the experiment, WT (n = 8), mdx Con (n = 13), mdx Sim 40 (n = 11), mdx Sim 80 (n = 12). Echocardiography measurements of (C) FS% and (D) EF% are shown at 12 and 18 months of age. **P < 0.01 versus mdx Sim 80, ***P < 0.001 versus mdx Con and mdx Sim 40.