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. 2019 Mar 26;7(6):e14018. doi: 10.14814/phy2.14018

Figure 5.

Figure 5

Long‐term simvastatin treatment prevents fibrosis in cardiac muscle of mdx mice. (A) Representative images of fibronectin immunostaining (green) from cardiac muscle cross‐sections of 18‐month‐old WT, mdx Con and mdx Sim‐treated mice following 12 months of simvastatin treatment. Nuclei are labeled with DAPI (blue). The upper panel shows whole heart cross‐sections, while the lower panel shows a selected area at higher magnification. Scale bars, upper panel = 1 mm, lower panel = 100 μm. Note the patches of fibrosis in the mdx Con section (arrows). (B) Quantification of fibronectin immunofluorescence from cardiac muscle cross‐sections, showing individual and mean values. **P < 0.01 versus mdx Con, *P < 0.05 versus mdx Sim 40, ***P < 0.001 versus mdx Con, ***P < 0.001 versus mdx Con. WT (n = 10), mdx Con (n = 7), mdx Sim 40 (n = 7), mdx Sim 80 (n = 5).