Table 1.
Methylation data for novel identified genes in this study, SORD, DGKI, ICA1, and RNU6-499P.
| ENSEMBL ID | Chromosome | Starta | Enda | Symbol | Mean.Nb | Mean.PEb | Mean.diffb | Comb.p.valc | Comb.p.adj.fdrc | CombinedRankc |
|---|---|---|---|---|---|---|---|---|---|---|
| ENSG00000259352 | chr15 | 45365690 | 45366246 | SORD | 1 | 0.673809524 | 0.32619 | 1.86E-10 | 9.98E-06 | 888 |
| ENSG00000213238 | chr7 | 137982833 | 137983229 | DGKI | 1 | 0.912643994 | 0.087356 | 9.39E-10 | 2.52E-05 | 7238 |
| ENSG00000265212 | chr7 | 8194566 | 8194652 | ICA1 | 0 | 1 | -1 | 5.10E-07 | 0.007543012 | 3 |
| ENSG00000202485 | chr4 | 83095700 | 83095806 | RNU6-499P | 0.6667 | 1 | -0.33333 | 2.49E-06 | 0.026763498 | 843 |
aThe columns “Start” and “End” indicate the starting and ending chromosomal positions of the differentially methylated regions identified, as defined in the UCSC genome build hg19. bThe mean methylation coefficient β for each category of normotensive (mean.N), pre-eclamptic (mean.PE), and difference between these values (mean.diff), and the as defined by the software, Bismark. cThe statistical significance of difference between methylation extent of normotensive and pre-eclamptic samples calculated as a combined unadjusted p-value (comb.p.val) and a combined false-detection-rate-adjusted p-value (comb.p.adj.fdr).