Table 2.
Statistically significant variants from GWAS
| PMID | Gene | Year | Variant | ethnicity | OR (95% CI) | MAFb | P‐valuec | Cases/control | Power OR of 1.5 | FPRP values at prior probability of 0.001 at power OR of 1.5 | Ref. |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 20729852 | PLCE1 | 2010 | rs3765524 | Asian | 1.35 (1.22‐1.49) | 0.258/0.207 | 1.74E‐09 | 5417 (2115/3302) | 0.982 | 0.000 | 75 |
| PLCE1 | 2010 | rs2274223 | Asian | 1.43 (1.37‐1.49) | Na | 7.46E‐56 | 5417 (2115/3302) | 0.842 | 0.000 | 75 | |
| 20729853 | C20orf54 | 2010 | rs13042395 | Asian | 0.86 (0.82‐0.90) | Na | 1.21E‐11 | 22 336 (9053/13 283) | 1.000 | 0.000 | 24 |
| HEATR | 2012 | rs4785204 | Asian | 1.24 (1.18‐1.29) | Na/0.26 | 2.24E‐20 | 20 787 (10 123/10 664) | 1.000 | 0.000 | 24 | |
| 22960999 | HEATR | 2012 | rs7206735 | Asian | 1.20 (1.15‐1.26) | Na/0.28 | 1.97E‐16 | 20 787 (10 123/10 664) | 1.000 | 0.000 | 76 |
| HAP1 | 2012 | rs6503659 | Asian | 1.27 (1.20‐1.34) | Na/0.13 | 2.73E‐10 | 20 787 (10 123/10 664) | 1.000 | 0.000 | 76 | |
| XBP1 | 2012 | rs2239815 | Asian | 1.18 (1.13‐1.23) | Na/0.37 | 3.88E‐15 | 20 787 (10 123/10 664) | 1.000 | 0.000 | 76 | |
| ST6GAL1 | 2012 | rs2239612 | Asian | 1.21 (1.15‐1.27) | Na/0.19 | 5.74E‐15 | 20 787 (10 123/10 664) | 1.000 | 0.000 | 76 | |
| SMG6 | 2012 | rs17761864 | Asian | 1.21 (1.14‐1.28) | Na/0.14 | 2.21E‐11 | 20 787 (10 123/10 664) | 1.000 | 0.000 | 76 | |
| PTPN2 | 2012 | rs2847281 | Asian | 1.20 (1.14‐1.26) | Na/0.16 | 2.49E‐11 | 20 787 (10 123/10 664) | 1.000 | 0.000 | 76 | |
| CHEK2 | 2012 | rs4800983 | Asian | 1.27 (1.21‐1.34) | Na/0.20 | 1.94E‐22 | 20 787 (10 123/10 664) | 1.000 | 0.000 | 76 | |
| CHEK2 | 2012 | rs1033667 | Asian | 1.25 (1.19‐1.30) | Na/0.25 | 4.85E‐22 | 20 787 (10 123/10 664) | 1.000 | 0.000 | 76 | |
| 24121790 | KLF5 | 2015 | rs1924966 | Asian | 0.84 (0.80‐0.89) | 0.35/0.40 | 1.37E‐10 | 12 356 (6177/6179) | 1.000 | 0.000 | 27 |
| 26315552 | KLF5 | 2015 | rs115797771 | Asian | 0.69 (0.62‐0.78) | 0.05/0.06 | 2.32E‐10 | 12 356 (6177/6179) | 0.709 | 0.000 | 28 |
| KLF5 | 2015 | rs58090485 | Asian | 0.69 (0.62‐0.77) | 0.05/0.07 | 1.23E‐10 | 12 356 (6177/6179) | 0.731 | 0.000 | 28 | |
| TMEM173a | 2014 | rs7447927 | Asian | 0.85 (0.82‐0.88) | Na | 7.72E‐20 | 30 286 (15 667/14 619) | 1.000 | 0.000 | 28 | |
| 25129146 | ATP1B2a | 2014 | rs1642764 | Asian | 0.88 (0.85‐0.91) | Na | 3.10E‐13 | 30 281 (15 474/14 807) | 1.000 | 0.000 | 77 |
Na, Not available.
a
The SNP is near the genes in brackets.
b
Minor Allele Frequency (MAF) in Case/Control.
c
The P values are all <1.00E‐08.