Table 3.

Expression of serum exosomal proteins in African American men with PCa (PAA) with respect to Caucasian men with PCa (PCC)

	Fold change
Top 10 upregulated proteins in PAA in comparison with PCC
Isoform 2 of Eukaryotic translation initiation factor 2‐alpha kinase 4	34
Keratin, type I cytoskeletal 10	10
SCO‐spondin	5.3
Serum amyloid P‐component	4
Apolipoprotein(a)	3.9
Keratin, type I cytoskeletal 9	3
Ig kappa chain V‐IV region	2.4
Isoform 2 of Filamin A	2.4
Keratin, type II cytoskeletal 1	2.6
Keratin, type II cytoskeletal 2 epidermal	2.3
Top 10 downregulated proteins in PAA in comparison with PCC
Ig heavy chain V‐III region BRO	0.1
Alpha‐1‐antitrypsin	0.1
Plasminogen	0.1
Ig heavy chain V‐III region TIL	0.1
Hemopexin	0.1
Afamin	0.1
Inter‐alpha‐trypsin inhibitor heavy chain H1	0.1
Protein AMBP	0.1
Alpha‐1B‐glycoprotein	0.03
Complement component C8 alpha chain	0.06
Unique proteins present in PAA as compared to PCC
Coiled‐coil domain‐containing protein 172, DnaJ homolog subfamily C member 13, Ig kappa chain V‐I region EU, UPF0728 protein C10orf53, and Isoform 2 of Coiled‐coil and C2 domain‐containing protein 1A