Table 2.
Univariate and multivariate analyses for EFS, OS, and RFS according to CD9 expression and other biological parameters
| EFS |
Univariate HR (range) P‐value |
Multivariate HR (range) P‐value |
|---|---|---|
| Age |
1.024 (1.006‐1.043) P = 0.01 |
1.012 (0.99‐1.03) P = 0.27 |
| FAB type |
1.002 (0.822‐1.222) P = 0.98 |
NI |
| Cytogenetic risk |
4.28 (2.46‐7.45) P < 0.001 |
P = 4.9 (2.65‐9.06) P < 0.001 |
| FLT3‐ITD |
2.4 (1.31‐4.32) P = 0.004 |
3.32 (1.68‐6.59) P = 0.001 |
| NPM1 mutation |
0.82 (0.41‐1.62) P = 0.19 |
NI |
| CD9 + blasts |
0.46 (0.26‐0.82) P = 0.009 |
0.35 (0.17‐0.72) P = 0.004 |
| OS |
Univariate HR (range) P‐value |
Multivariate HR (range) P‐value |
|---|---|---|
| Age |
1.044 (1.017‐1.071) P = 0.001 |
1.03 (0.998‐1.064) P = 0.07 |
| WBC count (109/L) |
1.004 (1‐1.007) P = 0.035 |
0.999 (0.994‐1.004) P = 0.62 |
| FAB type |
0.964 (0.773‐1.278) P = 0.96 |
NI |
| Cytogenetic risk |
4.57 (2.37‐8.8) P < 0.001 |
4.53 (2.16‐9.45) P < 0.001 |
| FLT3‐ITD |
2.9 (1.39‐6.04) P = 0.004 |
1.538 (1.208‐2.39) P = 0.23 |
| NPM1 mutation |
0.74 (0.33‐1.69) P = 0.38 |
NI |
| CD9 + blasts |
0.613 (0.309‐1.217) P = 0.16 |
NI |
| RFS |
Univariate HR (range) P‐value |
Multivariate HR (range) P‐value |
|---|---|---|
| Age |
1.035 (1.011‐1.061) P = 0.004 |
1.044 (1.012‐1.077) P = 0.007 |
| WBC count (109/L) |
1.004 (1.001‐1.008) P = 0.02 |
0.998 (0.992‐1.004) P = 0.47 |
| FAB type |
1.084 (0.85‐1.38) P = 0.53 |
NI |
| Cytogenetic risk |
3.001 (1.54‐5.89) P = 0.001 |
3.29 (1.52‐7.13) P = 0.003 |
| FLT3‐ITD |
3.2 (1.5‐6.85) P = 0.003 |
2.55 (1.07‐6.05) P = 0.034 |
| NPM1 mutation |
0.96 (0.42‐2.21) P = 0.57 |
NI |
| CD9 + blasts |
0.496 (0.244‐1.008) P = 0.048 |
0.405 (0.172‐0.955) P = 0.039 |
P‐values number marked in bold are significant in multivariate analysis