Table 3.
Univariable Cox regression analysis of relationship of covariates with patient death within 5 years of PTLD diagnosis
| Variable | Reference group | Hazard Ratio (95% CI) | P‐value |
|---|---|---|---|
| Age at transplant (Years) | Each 1 year age increment | 1.01 (0.99, 1.03) | 0.18 |
| Male | Female | 0.97 (0.45,2.17) | 0.94 |
| Transplant type | |||
| Heart | Bone marrow | 0.33 (0.04,6.86) | 0.85 |
| Liver | Bone marrow | 0.78 (0.10,15.98) | |
| Lung | Bone marrow | 0.55 (0.10,10.15) | |
| Multi‐organ | Bone marrow | 0.58 (0.05,12.71) | |
| Kidney | Bone marrow | 0.40 (0.06,7.69) | |
| Locations of PTLD | |||
| Lymph node | Non‐lymph node location | 0.45 (0.15,1.09) | 0.10 |
| GI tract | Non‐GI tract location | 0.87 (0.34,1.97) | 0.74 |
| Liver | Non‐liver location | 4.15 (1.20,11.17) | 0.005 |
| CNS | Non‐CNS location | 6.74 (0.36,36.73) | 0.037 |
| Bone Marrow | Non‐bone marrow location | 14.74 (2.99,61.04) | <.001 |
| Lung | Non‐lung location | 0.43 (0.07,1.47) | 0.24 |
| Time from transplant to PTLD | |||
| 1 year or above | <1 year | 0.81 (0.37,1.90) | 0.61 |
| PTLD type | |||
| Polymorphic | Non‐polymorphic | 0.66 (0.24,1.54) | 0.36 |
| DLBCL | Non‐DLBCL | 1.25 (0.58,2.76) | 0.57 |
| Classic Hodgkin | Non‐Hodgkin | 0.35 (0.02,1.64) | 0.28 |
| T cell | Non‐T cell | 3.58 (1.04,9.40) | 0.013 |
| Burkitt lymphoma/plasma cell | Non‐Burkitt/Plasma | 0.74 (0.04,3.48) | 0.76 |
| Induction immunosuppression Regimen^ other | Anti‐thymocyte globulin | 0.87 (0.29,2.87) | 0.22 |
| Unknown | Anti‐thymocyte globulin | 0.55 (0.15,1.97) | |
| Anti‐IL2 receptor | Anti‐thymocyte globulin | 1.74 (0.56,5.89) | |
| Log TTV copies/μg of Human DNA * | Each 1 log increase | 1.10 (1.02,1.20) | 0.016 |
| TTV‐ copies/μg of Human DNA: >median * | TTV‐1 copies/μg of Human DNA: ≤ median | 2.23 (0.98,5.51) | 0.058 |
| Tumor EBV status (clinical testing) Any Positive@ | Negative | 0.55 (0.25,1.27) | 0.14 |
| Log EBV copies/μg of Human DNA* | Each 1 log increase | 1.01 (0.93, 1.11) | 0.76 |
| EBV copies/μg of Human DNA: > median* | EBV copies/μg of Human DNA: ≤ median | 1.28 (0.57,2.97) | 0.55 |
| MSS positive | |||
| EBV | Negative | 0.67 (0.31,1.47) | 0.30 |
| Cytomegalovirus | Negative | 0.52 (0.03,2.47) | 0.51 |
| HHV6 or 7 | Negative | 1.15 (0.52,2.49) | 0.73 |
| Simplexvirus | Negative | 2.45 (0.14,11.84) | 0.37 |
| BK_polyomavirus | Negative | 4.76 (0.26,24.46) | 0.10 |
| Merkel_cell_polyoma | Negative | 0.52 (0.03,2.48) | 0.52 |
| Alphapapillomavirus | Negative | 1.05 (0.06,4.94) | 0.97 |
| Betapapillomavirus | Negative | 1.75 (0.68,4.00) | 0.20 |
| Gammapapillomavirus | Negative | 2.38 (0.87,5.62) | 0.06 |
| Papillomaviridae | Negative | 1.85 (0.44,5.32) | 0.31 |
| Erythroparvovirus | Negative | 0.76 (0.12,2.54) | 0.70 |
| Anelloviridae | Negative | 2.00 (0.91,4.70) | 0.09 |
Number dead within 5 years = 26 and number alive at 5 years post‐PTLD = 34, except where marked separately.
^Number dead = 25, number alive = 34, *Number dead = 24, number alive = 33, @Number dead = 25, number alive = 30.
For log‐transformed PCR values, 1 was added to all values to account for PCR copy number = 0, as log 0 is not defined and log 1 = 0.
PTLD locations were not mutually exclusive.