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. 2019 Feb 22;17(4):2913–2920. doi: 10.3892/etm.2019.7301

Figure 5.

Figure 5.

HIF-1α combined with Bio-Oss upregulates the mRNA expression levels of the angiogenesis-associated genes. (A) HIF-1α and (B) VEGF, and the osteogenesis-associated genes (C) Runx2, (D) ALP and (E) OCN were indicated. Data are presented as mean ± standard deviation, n>3. *P<0.05, **P<0.01 and ***P<0.005 as indicated. HIF-1α, hypoxia-inducible factor-1α; VEGF, vascular endothelial growth factor; Runx2, runt-related transcription factor 2; ALP, alkaline phosphatase; OCN, osteocalcin.