Figure 6.

HIF-1α combined with Bio-Oss upregulates the protein expression levels of osteogenesis- and angiogenesis-associated factors in extraction sites. (A) Western blotting was used to detect the protein levels of OCN, Runx2, OSX, VEGF and HIF-1α in the bone tissues around the extraction sites. (B) Quantification of the protein levels in (A) by normalizing to β-actin. The results are presented as mean ± standard deviation, n>3. *P<0.05, **P<0.01 and ***P<0.005 as indicated. HIF-1α, hypoxia-inducible factor-1α; VEGF, vascular endothelial growth factor; Runx2, runt-related transcription factor 2; OCN, osteocalcin; OSX, osteoblast-specific transcription factor osterix.