Trial	Year	Location	Sites	Country mortality rate	WHO mortality strata	Region
RV1 Anh 2011‐PHL	2007	Philippines	1	Low‐mortality	B	Asia
RV1 Anh 2011‐VNM	2007	Vietnam	11	Low‐mortality	B	Asia
RV1 Bernstein 1998‐USA	1998	USA	1	Low‐mortality	A	North America
RV1 Bernstein 1999‐USA	1999	USA	2	Low‐mortality	A	North America
RV1 Colgate 2016‐BGD	2014	Bangladesh	1	High‐mortality	D	Asia
RV1 Dennehy 2005‐NA	2005	USA and Canada	41	Low‐mortality	A	North America
RV1 GSK[021] 2007‐PAN	2007	Panama	1	Low‐mortality	B	Latin America
RV1 GSK[033] 2007‐LA	2007	Colombia, Mexico, and Peru	(2 in Colombia, 1 in Mexico, and 4 in Peru)	High‐mortalitya	B, D	Latin America
RV1 GSK[041] 2007‐KOR	2007	South Korea	6	Low‐mortality	B	Asia
RV1 GSK[101555] 2008‐PHL	2008	Philippines	1	Low‐mortality	B	Asia
RV1 Kawamura 2011‐JPN	2009	Japan	18	Low‐mortality	A	Asia
RV1 Kerdpanich 2010‐THA	2005	Thailand	2	Low‐mortality	B	Asia
RV1 Kim 2012‐KOR	2010	Republic of Korea	19	Low‐mortality	B	Asia
RV1 Li 2013a‐CHN	2010	China	1	Low‐mortality	B	Asia
RV1 Li 2013b‐CHN	2010	China	1	Low‐mortality	B	Asia
RV1 Li 2014‐CHN	2012	China	4	Low‐mortality	B	Asia
RV1 Madhi 2010‐AF	2010	South Africa and Malawi	2	High‐mortality	E	Africa
RV1 Narang 2009‐IND	2009	India	4	High‐mortality	D	Asia
RV1 NCT00158756‐RUS	2006	Russian Federation	9	Low‐mortality	C	Europe
RV1 Omenaca 2012‐EU	2008	France, Poland, Portugal, and Spain	Multiple sites in each country	Low‐mortality	A, B	Europe
RV1 Phua 2005‐SGP	2005	Singapore	8	Low‐mortality	A	Asia
RV1 Phua 2009‐AS	2009	Hong Kong, Singapore, and Taiwan	3	Low‐mortality	A	Asia
RV1 Rivera 2011‐DOM	2008	Dominican Republic	1	Low‐mortality	B	Latin America
RV1 Ruiz‐Palac 06‐LA/EU	2006	Argentina, Brazil, Chile, Colombia, Dominican Republic, Finland, Honduras, Mexico, Nicaragua, Panama, Peru, and Venezuela	Multiple	Low‐mortalityb	A, B, D	Latin America/Europe
RV1 Salinas 2005‐LA	2005	Brazil, Mexico, and Venezuela	3	Low‐mortality	B	Latin America
RV1 Steele 2008‐ZAF	2007	South Africa	1	High‐mortality	E	Africa
RV1 Steele 2010a‐ZAF	2008	South Africa	5	High‐mortality	E	Africa
RV1 Steele 2010b‐ZAF	2007	South Africa	7	High‐mortality	E	Africa
RV1 Tregnaghi 2011‐LA	2008	Argentina, Brazil, Colombia, Dominican Republic, Honduras, and Panama	Multiple sites in each country	Low‐mortality	B	Latin America
RV1 Vesikari 2004a‐FIN	2004	Finland	2	Low‐mortality	A	Europe
RV1 Vesikari 2004b‐FIN	2004	Finland	6	Low‐mortality	A	Europe
RV1 Vesikari 2007a‐EU	2007	Czech Republic, Finland, France, Germany, Italy, and Spain	98	Low‐mortality	A	Europe
RV1 Vesikari 2011‐FIN	2005	Finland	5	Low‐mortality	A	Europe
RV1 Ward 2006‐USA	2006	USA	2	Low mortality	A	North America
RV1 Zaman 2009‐BGD	2005	Bangladesh	1	High‐mortality	D	Asia
RV1 Zaman 2017‐BGD	2011	Bangladesh	142	High‐mortality	D	Asia
RV5 Armah 2010‐AF	2009	Ghana, Kenya, and Mali	3	High‐mortality	D, E	Africa
RV5 Block 2007‐EU/USA	2007	Finland and USA	30	Low‐mortality	A	Europe and North America
RV5 Ciarlet 2009‐EU	2008	Austria, Belgium, and Germany	26	Low‐mortality	A	Europe
RV5 Clark 2003‐USA	2003	USA	19	Low‐mortality	A	North America
RV5 Clark 2004‐USA	2004	USA	10	Low‐mortality	A	North America
RV5 Dhingra 2014‐IND	2012	India	2	High‐mortality	D	Asia
RV5 Iwata 2013‐JPN	2009	Japan	32	Low‐mortality	A	Asia
RV5 Kim 2008‐KOR	2008	South Korea	8	Low‐mortality	B	Asia
RV5 Lawrence 2012‐CHN	2010	China	Not reported	Low‐mortality	B	Asia
RV5 Merck[009] 2005‐USA	2005	USA	10	Low‐mortality	A	North America
RV5 Mo 2017‐CHN	2015	China	5	Low‐mortality	B	Asia
RV5 Vesikari 2006a‐FIN	2006	Finland	4	Low‐mortality	A	Europe
RV5 Vesikari 2006b‐INT	2006	Belgium, Costa Rica, Finland, Germany, Guatemala, Italy, Jamaica, Mexico, Puerto Rico, Sweden, Taiwan, and USA	356	Low‐mortalityb	A, B, D	Asia, Caribbean, Europe, Latin America, North America
RV5 Zaman 2010‐AS	2009	Bangladesh and Vietnam	Multiple	High‐mortalitya	B, D	Asia
VAC Bhandari 2006‐IND	2005	India	1	High‐mortality	D	Asia
VAC Bhandari 2009‐IND	2006‐8	India	1	High‐mortality	D	Asia
VAC Bhandari 2014‐IND	2011‐13	India	3	High‐mortality	D	Asia
VAC Chandola 2017‐IND	2014‐15	India	1	High‐mortality	D	Asia