Figure 4.

AOM/DSS treatment affects mRNA levels of XBP1s, IRE1β and MUC2 in colon tissues of mice. Following a one-off treatment with AOM and three cycles of DSS, mRNA expression of IRE1α, XBP1u, XBP1s, IRE1β and MUC2 were determined in tissues from mice in the untreated control and tumor groups (n=10/group) at the end point of the experiment using reverse transcription-quantitative polymerase chain reaction assays. *P<0.05 vs. control group. AOM, azoxymethane; DSS, dextran sulfate sodium; IRE, inositol-requiring enzyme; XBP, X-box binding protein; MUC, mucin.